(S,R,S)-AHPC-Me hydrochloride

Supplier MedChemExpress
Product # HY-42424-1 g
CAS # 1948273-03-7
Pricing 1 g, USD $1000.0
Synonyms VHL ligand 2 hydrochloride; E3 ligase Ligand 1
MWt 481.05
Formula C₂₃H₃₃ClN₄O₃S
Biological Activity (S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2].
Purity 98.32%
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