Mouse Anti-TNFRSF8 Recombinant Antibody (clone T215)
Because CD30 is highly expressed on Hodgkin's lymphoma and anaplastic large cell lymphoma, it is a promising target for immunotherapy. The extracellular portion of CD30 is cleaved, releasing a form known as soluble CD30 ("sCD30"), which can reduce the effects of CD30-targeting agents by competitive binding. The antibody binds to the membrane-specific epitopes (Ep2) are located near the middle of the extracellular domain of CD30 that are missing on soluble CD30. Ligands that bind to these epitopes can be used to target cells with intact CD30 without competition from sCD30.
| Supplier | Creative Biolabs |
|---|---|
| Product # | HPAB-0334-YC |
| Pricing | Inquiry |
| Host | Mouse |
| Target | TNFRSF8 |
| Species Reactivity | Human |
| Type | Mouse IgG1, κ |
| Applications | ELISA, FC, WB |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |