Idalopirdine HCl
Idalopirdine, also known as Lu AE58054 or Iladopirdine, is a potent and selective 5-HT6 receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia. It is in phase III clinical trials. Lu AE58054 displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a Ki of 0.83 nm. Lu AE58054 demonstrated >50-fold selectivity for more than 70 targets examined. Lu AE58054 is a selective antagonist of 5-HT(6)Rs with good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia. Lu AE58054 may be useful for the pharmacotherapy of cognitive dysfunction in disease states such as schizophrenia and Alzheimer's disease.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1557 |
| CAS # | 467458-02-2 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | Lu AE58054; Lu AE-58054; Lu AE 58054; Idalopirdine; Iladopirdine HCl; Iladopirdine hydrochloride |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H20ClF5N2O |
| Exact Mass | 398.1418 |
| Molecular Weight | 434.835 |
| Elemental Analysis | C, 55.24; H, 4.64; Cl, 8.15; F, 21.85; N, 6.44; O, 3.68 |
| IUPAC/Chemical Name | 2-(6-fluoro-1H-indol-3-yl)-N-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)ethanamine hydrochloride |
| InChi Key | KXOQNPANAFXKTN-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C20H19F5N2O.ClH/c21-15-4-5-17-14(11-27-18(17)9-15)6-7-26-10-13-2-1-3-16(8-13)28-12-20(24,25)19(22)23;/h1-5,8-9,11,19,26-27H,6-7,10,12H2;1H |
| SMILES Code | FC1=CC2=C(C=C1)C(CCNCC3=CC=CC(OCC(F)(F)C(F)F)=C3)=CN2.[H]Cl |
| Appearance | White to off-white solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |