Mouse Anti-PLCG1 Recombinant Antibody (clone F7)
Provided is a antibody as a blocker for PLC-γ1 mediated signaling. Antibody, designated F7, bound to PLC-γ1 with high affinity in vitro. F7 also bound to PLC-γ1 in vivo and altered the distribution pattern of PLC-g1 from the cytoplasm to the intracellular aggregates, where F7 was localized. Moreover, F7 interrupted the EGF-induced translocation of PLC-γ1 from the cytosol to the membrane rue and attenuated EGF-induced inositol phosphates generation and intracellular calcium mobilization.
| Supplier | Creative Biolabs |
|---|---|
| Product # | FAMAB-0249YC |
| Pricing | Inquiry |
| Host | Mouse |
| Target | PLCG1 |
| Type | Mouse IgG |
| Applications | ELISA, IP, WB |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |