Human Anti-HLA-B27 Recombinant Antibody (clone HD6)
Provided is an antibody, which binds to HLA-B27 heavy-chain homodimers, termed HC-B27, HLA-B272 or B272, particularly recognizing B272 homodimers and which does not recognize or bind HLA-B27 heterotrimers (B27) including HLA-B27 heterotrimers with β2 microglobulin and peptide. It has shown that HD6 bound to recombinant B272 complexes but not to HLA-A2, B7 or B27 complexes in ELISA. HD6 inhibited binding of B272 to KIR3DL1, KIR3DL2 and LILRB2 immunoreceptors and B272-mediated survival and proliferation of human NK cells expressing KIR3DL2.
| Supplier | Creative Biolabs |
|---|---|
| Product # | HPAB-J0122-YC |
| Pricing | Inquiry |
| Host | Human |
| Target | HLA-B27 |
| Species Reactivity | Human |
| Type | Human IgG1 |
| Applications | FC, Block, Inhib |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |