(S,R,S)-AHPC-Me hydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-42424-100 mg |
| CAS # | 1948273-03-7 |
| Pricing | 100 mg, USD $300.0 |
| Synonyms | VHL ligand 2 hydrochloride; E3 ligase Ligand 1 |
| MWt | 481.05 |
| Formula | C₂₃H₃₃ClN₄O₃S |
| Biological Activity | (S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2]. |
| Purity | 98.32% |