ADX88178
ADX-88178 is a novel potent, selective, and brain-penetrant positive allosteric modulator of the mGlu4 receptor in rodent models of anxiety, obsessive compulsive disorder (OCD), fear, depression, and psychosis. ADX88178 dose-dependently reduced the number of buried marbles in the marble burying test and increased open-arm exploration in the elevated plus maze (EPM) test, indicative of anxiolytic-like efficacy.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1389 |
| CAS # | 1235318-89-4 |
| Pricing | Customizable size, Inquiry |
| Synonym | ADX-88178; ADX 88178; ADX88178. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C12H12N6S |
| Exact Mass | 272.0844 |
| Molecular Weight | 272.33 |
| Elemental Analysis | C, 52.93; H, 4.44; N, 30.86; S, 11.77 |
| IUPAC/Chemical Name | 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)thiazol-2-amine |
| InChi Key | MIQNXKWDQRNHAU-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18) |
| SMILES Code | CC1=NC(NC2=NC(C3=CNN=C3)=C(C)S2)=NC=C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Anxiety |
| Availability | 2 Weeks |