(S)-BI 665915
(S)-BI 665915 is an orally active inhibitor of 5-lipoxygenase-activating protein (FLAP) containing oxadiazole, with an IC50 of 1.7 nM for binding to FLAP. It inhibits the function of FLAP in human whole blood with an IC50 of 45 nM. It has excellent cross-species drug metabolism and pharmacokinetic (DMPK) properties, and has a dose-dependent inhibition of LTB4 production.
| Supplier | BOC Sciences |
|---|---|
| Product # | 1360550-05-5 |
| Pricing | Inquire |
| Cas | 1360550-05-5 |
| Molecular Weight | 458.52 |
| Molecular Formula | C24H26N8O2 |
| Canonical SMILES | CC(C1CC1)(C2=CC=C(C=C2)C3=CN=C(N=C3)N)C4=NOC(=N4)C5=CN(N=C5)CC(=O)N(C)C |