MK-8189
MK-8189 is a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia. MK-8189 exhibited moderate plasma clearance and relatively low volume of distribution in rats and rhesus monkeys, resulting in a half-life of 4.8 h in rats and 4.2 h in rhesus monkeys. Oral bioavailability ranged from 41% in rhesus monkeys to 46% in rats. MK-8189 has an excellent profile against ion channels (Iks, Cav1.2, and Nav1.5 > 30 μM, and functional hERG Ikr IC50 = 33 μM). MK-8189 was efficacious in a test of episodic memory, the novel objection recognition assay in rats.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1588 |
| CAS # | 1424371-93-6 (SS-isomer) |
| Pricing | Customizable size, Inquiry |
| Synonym | MK-8189; MK8189; MK 8189 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C19H22N6OS |
| Exact Mass | 382.16 |
| Molecular Weight | 382.49 |
| Elemental Analysis | C, 59.66; H, 5.80; N, 21.97; O, 4.18; S, 8.38 |
| IUPAC/Chemical Name | 2-methyl-N-((5-methyl-1,3,4-thiadiazol-2-yl)methyl)-6-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-4-amine |
| InChi Key | WQKPZDLZRFTMTI-CABCVRRESA-N |
| InChi Code | InChI=1S/C19H22N6OS/c1-11-4-5-16(20-8-11)15-6-14(15)10-26-18-7-17(22-12(2)23-18)21-9-19-25-24-13(3)27-19/h4-5,7-8,14-15H,6,9-10H2,1-3H3,(H,21,22,23)/t14-,15+/m1/s1 |
| SMILES Code | CC1=NN=C(CNC2=NC(C)=NC(OC[C@@H]3[C@@H](C4=NC=C(C)C=C4)C3)=C2)S1 |
| Appearance | To be determined |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |