| Supplier |
Creative Peptides |
| Product # |
R1852 |
| CAS # |
579492-81-2 |
| Pricing |
Inquire
|
| LabelingTarget |
Apoptosis
|
| Synonyms |
BIP-V5
|
| MolecularFormula |
C27H50N6O6S
|
| MolecularWeight |
586.8
|
| Source |
Synthetic
|
| Sequence |
- One Letter Code: VPMLK
- Three Letter Code: H-Val-Pro-Met-Leu-Lys-OH
|
| Storage |
Store at -20°C.
|
| ShippingCondition |
Evaluation sample solution : ship with blue ice; All other available size: ship with RT , or blue ice upon request
|
| Explanation |
BAX Inhibiting Peptide V5 protects Bax against conformational changes and it also prevents mitochondrial translocation. In vitro analysis prove that peptide V5 prevents apoptosis, mediated by a number of agents including staurosporine, ultraviolet, and anti-cancer drug.
|
| ChemicalName |
(S)-6-amino-2-((Z)-((S)-2-((Z)-((S)-2-((Z)-(((S)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)(hydroxy)methylene)amino)-1-hydroxy-4-(methylthio)butylidene)amino)-1-hydroxy-4-methylpentylidene)amino)hexanoic acid
|
| Activity |
Inhibitor
|
| InChI |
InChI=1S/C27H50N6O6S/c1-16(2)15-20(24(35)31-19(27(38)39)9-6-7-12-28)32-23(34)18(11-14-40-5)30-25(36)21-10-8-13-33(21)26(37)22(29)17(3)4/h16-22H,6-15,28-29H2,1-5H3,(H,30,36)(H,31,35)(H,32,34)(H,38,39)/t18-,19-,20-,21-,22-/m0/s1
|
| InChIKey |
NHMUTADCTDDWPV-YFNVTMOMSA-N
|
| CanonicalSMILES |
CC(C)CC(C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CCSC)NC(=O)C1CCCN1C(=O)C(C(C)C)N
|
| Solubility |
≥29.35mg/mL in DMSO,insoluble in EtOH, ≥91.4 mg/mL in H2O
|
| IsomericSMILES |
CC(C)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)N
|
| Appearance |
Crystalline solid
|
| Purity |
≥97% (HPLC)
|
| AreasOfInterest |
Cancer
|
| LongTermStorageConditions |
-20 °C
|