Angiotensin A
Angiotensin A is a potent endogenous vasoconstrictor octapeptide. It is a derivative of angiotensin II (Ang II) that differs from Ang II in having alanine instead of aspartic acid as the first amino acid. It shows similar affinity for AT1 and AT2 receptors as angiotensin II with Ki values of 1.6 and 2.3 nM in vitro. It causes pressor and renal vasoconstrictor effects in rodents by the AT1 receptor. It is inhibited by Candesartan but not by AT2 receptor ligands in vivo. It also increases inositol phosphate accumulation with a similar potency to Ang II with EC50 value of 6.7 nM.
| Supplier | BOC Sciences |
|---|---|
| Product # | 51833-76-2 |
| Pricing | Inquire |
| Cas | 51833-76-2 |
| Molecular Weight | 1002.18 |
| Molecular Formula | C49H71N13O10 |
| Canonical SMILES | CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)N |