Taurodeoxycholic Acid-d4 sodium salt
Taurodeoxycholic acid-d4 is intended for use as an internal standard for the quantification of taurodeoxycholic acid by GC- or LC-MS. Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid. Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally. Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1754 |
| CAS # | 2410279-82-0 (sodium salt) |
| Pricing | Customizable size, Inquiry |
| Synonym | Taurodeoxycholic Acid-d4 sodium salt; Taurodeoxycholic Acid d4 sodium salt; Sodium Taurodeoxycholate-d4; Sodium Taurodeoxycholate d4; TDCA-d4; TDCA d4; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C26H40D4NNaO6S |
| Exact Mass | 525.3038 |
| Molecular Weight | 525.7132 |
| Elemental Analysis | C, 59.40; H, 9.20; N, 2.66; Na, 4.37; O, 18.26; S, 6.10 |
| IUPAC/Chemical Name | sodium 2-((R)-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl-2,2,4,4-d4)pentanamido)ethane-1-sulfonate |
| InChi Key | YXHRQQJFKOHLAP-YPYHFUETSA-M |
| InChi Code | InChI=1S/C26H45NO6S.Na/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);/q;+1/p-1/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-;/m1./s1/i10D2,14D2; |
| SMILES Code | [H][C@@]12[C@@]([H])(CC[C@@]3(C([2H])([C@@H](C([2H])(C[C@@]32C)[2H])O)[2H])[H])[C@@]([H])([C@@]4([C@H](C1)O)C)CC[C@@]4([C@@H](CCC(NCCS(=O)([O-])=O)=O)C)[H].[Na+] |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |