Aptazapine maleate
Aptazapine, also known as CGS 7525A, is a tetracyclic antidepressant (TeCA) which was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. It is a potent α2-adrenergic receptor antagonist with ~10x the strength of the related compound mianserin and has also been shown to act as a 5-HT2 receptor antagonist and H1 receptor inverse agonist, while having no significant effects on the reuptake of serotonin or norepinephrine. Based on its pharmacological profile, aptazapine may be classified as a noradrenergic and specific serotonergic antidepressant (NaSSA).
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD678 |
| CAS # | 71576-41-5 (maleate) |
| Pricing | Customizable size, Inquiry |
| Synonym | CGS 7525A; CGS-7525A; CGS7525A; Aptazapine maleate |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H23N3O4 |
| Molecular Weight | 369.421 |
| Elemental Analysis | C, 65.03; H, 6.28; N, 11.37; O, 17.32 |
| IUPAC/Chemical Name | 2-methyl-1,3,4,14b-tetrahydro-2H,10H-benzo[e]pyrazino[2,1-c]pyrrolo[1,2-a][1,4]diazepine maleate |
| InChi Key | JJTOHZLQMBVMPF-BTJKTKAUSA-N |
| InChi Code | InChI=1S/C16H19N3.C4H4O4/c1-17-9-10-19-14-6-3-2-5-13(14)11-18-8-4-7-15(18)16(19)12-17;5-3(6)1-2-4(7)8/h2-8,16H,9-12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1- |
| SMILES Code | CN(CC1)CC2N1C3=CC=CC=C3CN4C2=CC=C4.O=C(O)/C=C\C(O)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |