SB 224289
SB 224289 is a selective 5-HT1B receptor antagonist (pKi = 8.2). SB 224289 displays > 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. SB 224289 is a centrally active following oral administration in vivo.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD388 |
| CAS # | 180083-23-2 |
| Pricing | Customizable size, Inquiry |
| Synonym | SB 224289; SB224289; SB-224289. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C32H32N4O3 |
| Exact Mass | 520.2474 |
| Molecular Weight | 520.63 |
| Elemental Analysis | C, 73.82; H, 6.20; N, 10.76; O, 9.22 |
| IUPAC/Chemical Name | (1'-Methyl-6,7-dihydro-5H-spiro(furo(2,3-f)indole-3,4'-piperidin)-5-yl)(2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)methanone |
| InChi Key | ATQMRMGXINTJHV-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C32H32N4O3/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32/h4-9,16-18H,10-15,19H2,1-3H3 |
| SMILES Code | O=C(N1CCC2=C1C=C3C(OCC34CCN(C)CC4)=C2)C5=CC=C(C6=CC=C(C7=NOC(C)=N7)C=C6C)C=C5 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |