Human Anti-HIV-1 gp120 Recombinant Antibody (clone GL-VRC01)
Recombinant Human Antibody (GL-VRC01) is capable of binding to HIV-1 gp120, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp120 mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-HIV-1 gp120 proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. VRC01-class bNAbs all derive from the human VH1-2*02 variable heavy gene, but differ significantly in amino acid sequence and complementarity-determining region H3 (CDRH3) length and use a few different variable light chain genes.
| Supplier | Creative Biolabs |
|---|---|
| Product # | PABZ-165 |
| Pricing | Inquiry |
| Host | Human |
| Target | HIV-1 gp120 |
| Species Reactivity | HIV-1 |
| Type | Human IgG |
| Applications | Neut Assay-Dependent |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |