Mexazolam
Mexazolam is a drug which is a benzodiazepine derivative. Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up, however, after three weeks of therapy mexazolam had lost its therapeutic anxiolytic properties becoming no more effective than placebo, presumably due to benzodiazepine tolerance. Mexazolam is metabolised via the CYP3A4 pathway. HMG-CoA reductase inhibitors including simvastatin, simvastatin acid, lovastatin, fluvastatin, atorvastatin and cerivastatin inhibit the metabolism of mexazolam, but not the HMG-CoA reductase inhibitor pravastatin.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD282 |
| CAS # | 31868-18-5 |
| Pricing | Customizable size, Inquiry |
| Synonym | CS386; CS-386; CS 386; Melex; Sedoxil; Mexazolam |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C18H16Cl2N2O2 |
| Exact Mass | 362.0589 |
| Molecular Weight | 363.238 |
| Elemental Analysis | C, 59.52; H, 4.44; Cl, 19.52; N, 7.71; O, 8.81 |
| IUPAC/Chemical Name | 10-chloro-11b-(2-chlorophenyl)-3-methyl-2,3,7,11b-tetrahydrobenzo[f]oxazolo[3,2-d][1,4]diazepin-6(5H)-one |
| InChi Key | ANUCDXCTICZJRH-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C18H16Cl2N2O2/c1-11-10-24-18(13-4-2-3-5-15(13)20)14-8-12(19)6-7-16(14)21-17(23)9-22(11)18/h2-8,11H,9-10H2,1H3,(H,21,23) |
| SMILES Code | O=C1NC2=CC=C(Cl)C=C2C(OCC3C)(C4=CC=CC=C4Cl)N3C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |