| Supplier |
CD BioSciences |
| Product # |
AMA-0240 |
| Pricing |
, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB, IHC
|
| Product Usage Information Dilution |
Western Blotting (0.5-4 µg/mL)
|
| Reactivity |
Human, Mouse, Rat, Chicken
|
| Host |
Rabbit
|
| Gene ID |
25054
|
| Source/Isotype |
Rabbit IgG
|
| Storage |
Store at -20°C.
|
| Purification |
Affinity purified
|
| Background |
Due to the various splice variants, the trk proteins exist as variably glycosylated entities with the major forms having molecular weights of 140-145 kDa, 110 kDa and the unglycosylated form of 80 kDa. trkB contains 33.3% carbohydrate by weight representing modification on 10 of 12 N-glycosylation sites. The primary ligand for trkB is BDNF which induces the phosphorylation of the protein and subsequent binding of PLC-gamma via SH2 domains. TrkB may function to modulate neuronal responses to the neurotrophins acting throμgh trkB such as BDNF.
|