SPDB crosslinker
SPDB is useful heterobifunctional cross-linker, which is widely used to conjugate a small molecule drug to a targeted carrier (such as antibody, enzyme, protein and polymer). SPDB can be used to make ADC (antobody drug conjugate. Conjugated to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1199 |
| CAS # | 115088-06-7 |
| Pricing | Customizable size, Inquiry |
| Synonym | SPDB, SPDB disulfide heterobifunctional cross-linker. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C13H14N2O4S2 |
| Exact Mass | 326.0395 |
| Molecular Weight | 326.385 |
| Elemental Analysis | C, 47.84; H, 4.32; N, 8.58; O, 19.61; S, 19.65 |
| IUPAC/Chemical Name | N-Succinimidyl 4-(2-pyridyldithio)butanoate |
| InChi Key | JSHOVKSMJRQOGY-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C13H14N2O4S2/c16-11-6-7-12(17)15(11)19-13(18)5-3-9-20-21-10-4-1-2-8-14-10/h1-2,4,8H,3,5-7,9H2 |
| SMILES Code | O=C(ON1C(CCC1=O)=O)CCCSSC2=NC=CC=C2 |
| Appearance | Fluffy white solid powder |
| Purity | >95% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |