Raseglurant
Raseglurant (INN) (code name ADX-10059) is a negative allosteric modulator of the mGlu5 receptor and derivative of MPEP which was under development by Addex Therapeutics for the treatment of migraine, gastroesophageal reflux disease, and dental anxiety. It reached phase II clinical trials for all of the aforementioned indications before being discontinued due to the observation of possible predictive signs of hepato toxicity in patients with long-term use.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD338 |
| CAS # | 757950-09-7 |
| Pricing | Customizable size, Inquiry |
| Synonym | Raseglurant |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C15H13FN2 |
| Exact Mass | 240.1063 |
| Molecular Weight | 240.2814 |
| Elemental Analysis | C, 74.98; H, 5.45; F, 7.91; N, 11.66 |
| IUPAC/Chemical Name | 2-[2-(3-Fluorophenyl)ethynyl]-4,6-dimethylpyridin-3-amine |
| InChi Key | MEDCLNYIYBERKO-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C15H13FN2/c1-10-8-11(2)18-14(15(10)17)7-6-12-4-3-5-13(16)9-12/h3-5,8-9H,17H2,1-2H3 |
| SMILES Code | NC1=C(C)C=C(C)N=C1C#CC2=CC=CC(F)=C2 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |