Vornorexant hydrate
Vornorexant, also known as ORN-0829 and TS-142, is a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia. Vornorexant is a dual orexin OX1 and OX2 receptor antagonist (DORA). Vornorexant has a time to peak of 2.5 hours and a relatively short elimination half-life of 1.3 to 3.3 hours. It was designed to have a short half-life and duration in order to reduce next-day side effects like
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1338 |
| CAS # | 1793073-92-3 (hydrate) |
| Pricing | Customizable size, Inquiry |
| Synonym | ORN-0829 hydrate; ORN0829; ORN 0829; ORN-0829; TS-142; TS 142; TS142; Vornorexant; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C23H24FN7O3 |
| Molecular Weight | 465.49 |
| Elemental Analysis | C, 59.35; H, 5.20; F, 4.08; N, 21.06; O, 10.31 |
| IUPAC/Chemical Name | Methanone, ((2S)-2-((3-(5-fluoro-2-pyridinyl)-1H-pyrazol-1-yl)methyl)dihydro-2H-1,3-oxazin-3(4H)-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)-, hydrate (1:1) |
| InChi Key | UFULGSDLQZYMCH-FTBISJDPSA-N |
| InChi Code | InChI=1S/C23H22FN7O2.H2O/c1-16-3-6-21(31-26-8-9-27-31)18(13-16)23(32)30-10-2-12-33-22(30)15-29-11-7-20(28-29)19-5-4-17(24)14-25-19;/h3-9,11,13-14,22H,2,10,12,15H2,1H3;1H2/t22-;/m0./s1 |
| SMILES Code | O=C(N1[C@H](CN2N=C(C3=NC=C(F)C=C3)C=C2)OCCC1)C4=CC(C)=CC=C4N5N=CC=N5.[H]O[H] |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |