Recombinant Human IFNGR1 Protein, His-tagged

IFNGR1, also known as interferon gamma receptor 1, is a member of the hematopoietic cytokine receptor superfamily. It is a receptor that binds interferon-γ, the sole member of interferon type II. It induces the rapid dimerization of chains, thereby forming a site that is recognized by the extracellular domain of IFNGR2. It is expressed in a membrane-bound form in many cell types, and is over-expressed in tumour cells. Its signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. It is crucial for host defence against mycobacterial infections. It is associated with susceptibility to pulmonary tuberculosis (TB).

• Supplier: Creative Biomart
• Product #: IFNGR1-001H