Binimetinib, Free Base (ARRY162, ARRY438162, MEK162, CAS 606143-89-9)

LC Laboratories' Product Number B-2332 - Binimetinib, Free Base (ARRY162, ARRY438162, MEK162, CAS 606143-89-9), >99% - for research use only. Binimetinib, also known as MEK162, is a novel, second generation MEK1/2 inhibitor. N-RAS mutant melanoma cultures appeared to be particularly sensitive to binimetinib, which reduced ERK1/2 phosphorylation, induced apoptosis, and significantly reduced clonogenic survival. Binimetinib induced transient retinopathy with multiple bilateral lesions in some patients with metastatic melanoma. Binimetinib showed some activities in patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations in a open-label, non-randomised, phase 2 study. Other CAS numbers previously assigned to Binimetinib free base, namely 1073666-70-2; 1201685-05-3 and 1417448-81-7, have been deleted by CAS and are no longer in use.

• Supplier: LC Laboratories
• Product #: B-2332
• Sku #: B-2332_100mg