HTL14242
HTL14242 is a mGlu5 Negative Allosteric Modulator. Metabotropic glutamate receptors (mGluRs) constitute the class C of G-protein coupled receptors (GPCRs) and play a key role in glutamatergic signaling. The inhibition of mGluR5, which is mostly expressed in the striatum, hippocampus, amygdala, and frontal cortex, is therefore considered as a potential therapeutic intervention in a number of psychiatry indications, including fragile X syndrome, anxiety, and depression.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD208 |
| CAS # | 1644645-32-8 |
| Pricing | Customizable size, Inquiry |
| Synonym | HTL14242; HTL-14242; HTL 14242. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C16H8ClFN4 |
| Exact Mass | 310.0422 |
| Molecular Weight | 310.7164 |
| Elemental Analysis | C, 61.85; H, 2.60; Cl, 11.41; F, 6.11; N, 18.03 |
| IUPAC/Chemical Name | 3-chloro-5-(6-(5-fluoropyridin-2-yl)pyrimidin-4-yl)benzonitrile |
| InChi Key | FQAXDSVNYVVQSE-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C16H8ClFN4/c17-12-4-10(7-19)3-11(5-12)15-6-16(22-9-21-15)14-2-1-13(18)8-20-14/h1-6,8-9H |
| SMILES Code | N#CC1=CC(C2=NC=NC(C3=NC=C(F)C=C3)=C2)=CC(Cl)=C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |