IDE-1
IDE-1 was identified in a high throughput screen as an inducer of definitive endoderm (IDE) from embryonic stem (ES) cells. IDE-1 is able to generate Sox17+/FoxA2+ cells to an equal or greater efficiency than that of protein (i.e. Activin A or Nodal) IDEs in mouse or human ES cell cultures. It functions in part via activation of TGF-β signaling, as evident by Smad2 phosphorylation. IDE-1 chemically induced endoderm can continue to differentiate into pancreatic progenitors in vitro and contribute to gut tube formation in vivo when injected into the developing gut tube of mouse embryos.
| Supplier | BOC Sciences |
|---|---|
| Product # | 1160927-48-9 |
| Pricing | Inquire |
| Cas | 1160927-48-9 |
| Molecular Weight | 306.31 |
| Molecular Formula | C15H18N2O5 |
| Canonical SMILES | O=C(O)CCCCCC(N/N=C/C1=CC=CC=C1C(O)=O)=O |