5'-DMT-2'-OMe-G(iBu)-3'-PS-Phosphoramidite

5'-DMT-2'-OMe-G(iBu)-3'-PS-Phosphoramidite is a specialized nucleotide compound employed in oligonucleotide synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position, a 2'-O-methyl modification on the ribose sugar, and a guanine base modified with an isobutyl (iBu) group. Additionally, it incorporates a phosphorothioate (PS) linkage at the 3' position. This phosphoramidite enables controlled addition during synthesis and offers enhanced stability and resistance to nuclease degradation in oligonucleotide sequences. It finds applications in molecular biology research, including gene synthesis, RNA interference, and nucleic acid probe development.

• Supplier: BOC Sciences
• Product #: BRP-00404
• Molecular Weight: 967.11
• Molecular Formula: C49H55N6O9PS2
• Canonical SMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N7CCCC7)SCCSC(=O)C8=CC=CC=C8)OC