PROTAC IDO1 Degrader-1
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-131911 |
| CAS # | 2488851-89-2 |
| Pricing | inquire |
| Biological Activity | PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. |
| MWt | 966.8 |
| Formula | C₄₀H₅₃BrFN₉O₁₃ |