MK-1775
MK-1775, also known as Adavosertib and AZD-1775, is a small molecule inhibitor of the tyrosine kinase WEE1 with potential anti-tumor sensitizing activity. MK-1775 selectively targets and inhibits WEE1 to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents CDC2 phosphorylation and impairs the G2 DNA damage checkpoint. This may lead to apoptosis following treatment with DNA damaging chemotherapeutic agents.
| Supplier | Alfa Cytology |
|---|---|
| Product # | BC0615 |
| Pricing | 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 200.0 mg, 500.0 mg, 1.0 g, 2.0 g, inquire |