| Background |
DEPTOR/DEPDC6 is a component of both mTORC1 and mTORC2 complexes It interacts with mTOR and inhibits mTORC1 and mTORC2 kinase activities mTOR, along with casein kinase I, phosphorylates DEPTOR/DEPDC6 in the presence of growth signals, which leads to the degradation of DEPTOR/DEPDC6 Research studies have shown that transgenic mice overexpressing DEPTOR/DEPDC6 have more white adipose tissue, and DEPTOR/DEPDC6 expression levels increase in the white adipose tissue of obese humans Furthermore, the expression of DEPTOR/DEPDC6 is induced during mouse adipocyte differentiation Together these findings suggest that DEPTOR/DEPDC6 regulates adipogenesis.
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