Recombinant Human NR3C2 Protein, His/GST-tagged
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Supplier | Creative Biomart |
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Product # | NR3C2-693H |
Pricing | 10ug : USD $398, 20ug : USD $498, 50ug : USD $698, 100ug : USD $998 |