N-piperidine Ibrutinib hydrochloride

Supplier MedChemExpress
Product # HY-130983-5 mg
CAS # 2231747-18-3
Pricing 5 mg, USD $200.0
Biological Activity N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively[1]. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[2].
MWt 422.91
Formula C₂₂H₂₃ClN₆O
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