| Supplier |
Creative Peptides |
| Product # |
R1836 |
| CAS # |
24769-58-2 |
| Pricing |
Inquire
|
| Synonyms |
TRH | Thyroliberin | Thyrotropin-releasing hormone | Prothyroliberin
|
| MolecularFormula |
C16H21N5O5
|
| MolecularWeight |
363.37
|
| Sequence |
- One Letter Code: Pyr-HP
- Three Letter Code: Pyr-His-Pro
|
| Storage |
-20 degrees Celsius away from light
|
| ShippingCondition |
Room temperature
|
| Explanation |
Thyrotropin-releasing hormone (TRH) is an endogenous tripeptide that acts as a neurotransmitter and neurohormone. TRH regulates hypothalamic-pituitary-adrenal (HPA) and estrogenic signaling pathways. TRH exhibits immunomodulatory and neuroprotective activities. TRH prevents oxidative stress, caspase-mediated apoptosis, glutamate toxicity, and neuroinflammation. Additionally, TRH stimulates epidermal regeneration in ex vivo models, increasing would healing. TRH activates the TRH receptor.
|
| InChI |
InChI=1S/C16H21N5O5/c22-13-4-3-10(19-13)14(23)20-11(6-9-7-17-8-18-9)15(24)21-5-1-2-12(21)16(25)26/h7-8,10-12H,1-6H2,(H,17,18)(H,19,22)(H,20,23)(H,25,26)/t10-,11-,12-/m0/s1
|
| InChIKey |
ITYONPBTNRIEBA-SRVKXCTJSA-N
|
| CanonicalSMILES |
C1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=O)O
|
| Solubility |
Soluble in H2O
|
| IsomericSMILES |
C1C[C@H](N(C1)C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@@H]3CCC(=O)N3)C(=O)O
|
| Appearance |
White or off-white lyophilized powder
|
| Purity |
> 95%
|