α-cyclodextrin
Cyclodextrins occur as white, practically odorless, fine crystalline powders, having a slightly sweet taste. Some cyclodextrin derivatives occur as amorphous powders.
| Supplier | CD Formulation |
|---|---|
| Product # | PE-0501 |
| Pricing | , Inquire for price |
| product1 | Stabilizers |
| Molecular Formula | (C6H10O5)6 |
| Molecular Weight | 972.84 |
| Applications | Mainly used for injectable preparations; However, because its cavity is the smallest among cyclodextrins, inclusion complexes can only be formed with relatively few molecules of small size. Fiber supplement administration; The carrier of a spice (an admixture of a spice); Carrier; Stabilizer or solvent enhancer; Vitamins and fatty acids; Improve the taste in drinks. |
| Safety | a-Cyclodextrin LD50 (rat, IP): 1.0 g/kg LD50 (rat, IV): 0.79 g/kg |
| Incompatibilities | The presence of cyclodextrin in aqueous solution may reduce the activity of some antibacterial preservatives. |
| Synonyms | alfadexum; alpha-cycloamylose; alpha-cyclodextrin; alpha-dextrin; Cavamax W6 Pharma; cyclohexaamylose; cyclomaltohexose |
| CAS Number | 10016-20-3 |
| Category | Solubilizing Agents; Stabilizing Agents |
| UNII | Z1LH97KTRM |
| Chemical Name | α-cyclodextrin |
| Grade | Pharmceutical Excipients |
| Administration route | Injection |
| Dosage Form | Injection preparations |
| Source and Preparation | Cyclodextrin is prepared by enzymolysis of amylase using special bacteria. The first step in the preparation of cyclodextrin (food grade), the starch paste is prepared by cyclodextrin glucose-transferase (CGTase, EC 2.4.1.19, CAS 9030-09-5) under controlled pH and temperature conditions. CGTase is derived from recombinant Escherichia coli. CGTase gene of Bacillus occitorella was latent. Alphacyclodextrin is precipitated by the addition of 1-decyl alcohol in an enzymatic reaction. Purification is obtained by solubility in water and reprecipitation. The added 1-decanol was separated from afacyclodextrin by reanalysis and steam distillation. Finally, afacyclodextrin was obtained by crystallization and white powder purity ≥ 98.0%. |