| Supplier |
CD BioSciences |
| Product # |
AMA-0434 |
| Pricing |
20 µL/100 µL, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB, IP
|
| Product Usage Information Dilution |
Western Blotting (1:1000); Immunoprecipitation (1:50)
|
| Reactivity |
Human, Monkey
|
| Gene ID |
8451
|
| UniProt ID |
|
| MW (Target) |
80 kDa
|
| Storage |
Store at -20°C. Do not aliquot the antibody.
|
| Purification |
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding residues surrounding Ser12 of human CUL4A. Antibodies are purified by peptide affinity chromatography.
|
| Background |
Cullin-4 (CUL4) is a member of the cullin family of related ubiquitin ligases A pair of mammalian CUL4 proteins - CUL4A and CUL4B - has been identified. The carboxy-terminal domain of CUL4 interacts with Rbx1 and E2 enzyme while the amino-terminal CUL4 domain interacts with BPB domain of UV-damaged DNA binding protein DDB1 to form a CUL4-DDB1 ubiquitin ligase complex This CUL4-DDB1 complex binds a variety of WD40-containing proteins that help to enhance additional substrate recruitment The CUL4 complex has been shown to target substrates involved in DNA repair, cell cycle progression transcription and development.
|