GW2580, Free Base (cFMS Receptor Tyrosine Kinase Inhibitor, CSF-1 Receptor Inhibitor, CAS 870483-87-7), >99%
LC Laboratories' Product Number G-5903 - GW2580, Free Base (cFMS Receptor Tyrosine Kinase Inhibitor, CSF-1 Receptor Inhibitor, CAS 870483-87-7), >99% - for research use only. GW2580 is a small-molecule inhibitor of cFMS kinase; at 60 nM it inhibited human cFMS kinase completely in vitro and was inactive against 26 other kinases. GW2580 inhibited lipopolysaccharide (LPS)-induced TNF production in mice, but not LPS-induced TNF production in freshly isolated human monocytes and mouse macrophages in vitro. Also, GW2580 at 1 µM totally inhibited CSF-1-induced growth of mouse M-NFS-60 myeloid cells and human monocytes, and prevented bone degradation in cultures of rat calvaria and rat fetal long bone in vitro. In an arthritic rat model, GW2580 inhibited joint connective tissue and bone destruction, and thus preserved joint integrity.
| Supplier | LC Laboratories |
|---|---|
| Product # | G-5903 |
| Sku # | G-5903_300mg |
| Pricing | 300 mg, $207.00 |
Citations for this product:
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bioRxiv - Cancer Biology 2024Quote: ... GW2580 a small molecule inhibitor of CSF-1R (cat# G-5903, LC Laboratories, Woburn, MA, USA) was dissolved in DMSO was used at a concentration of 100 nM ...