Dolutegravir
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-13238-500 mg |
| CAS # | 1051375-16-6 |
| Pricing | 500 mg, USD $1100.0 |
| Synonyms | S/GSK1349572 |
| MWt | 419.38 |
| Formula | C₂₀H₁₉F₂N₃O₅ |
| Biological Activity | Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2]. |
| Purity | 99.95% |