| Supplier |
CD BioSciences |
| Product # |
AMA-0603 |
| Pricing |
100 µL, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB
|
| Product Usage Information Dilution |
Western Blotting (1:1000)
|
| Reactivity |
Human, Mouse, Rat, Hamster, Monkey
|
| Host |
Rabbit
|
| Gene ID |
3678
|
| UniProt ID |
|
| Source/Isotype |
Rabbit IgG
|
| MW (Target) |
150 kDa
|
| Storage |
Store at -20°C. Do not aliquot the antibody.
|
| Purification |
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly117 of human Integrin α5 protein.
|
| Background |
Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling)Integrin α5/β1 is involved in multiple biological processes including embryonic development, angiogenesis and tumor metastasis By interaction with its fibronectin ligand, α5/β1 transduces signals that regulate cell adhesion, migration, matrix assembly and cytoskeletal organization.
|