PD184161
PD184161 is an orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner more effectively than PD098059 or U0126. PD184161 inhibited cell proliferation and induced apoptosis at concentrations of > or = 1.0 microM in a time- and concentration-dependent manner. PD184161 has antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity. PD184161 is unable to suppress MEK activity in HCC xenografts in the long term.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1095 |
| CAS # | 212631-67-9 |
| Pricing | Customizable size, Inquiry |
| Synonym | PD184161; PD 184161; PD184161; PF1529483 PF3011370 UK287074. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C17H13BrClF2IN2O2 |
| Exact Mass | 555.8862 |
| Molecular Weight | 557.5583 |
| Elemental Analysis | C, 36.62; H, 2.35; Br, 14.33; Cl, 6.36; F, 6.81; I, 22.76; N, 5.02; O, 5.74 |
| IUPAC/Chemical Name | 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide |
| InChi Key | VJNZMSLGVUSPCF-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C17H13BrClF2IN2O2/c18-11-6-10(17(25)24-26-7-8-1-2-8)16(15(21)14(11)20)23-13-4-3-9(22)5-12(13)19/h3-6,8,23H,1-2,7H2,(H,24,25) |
| SMILES Code | O=C(NOCC1CC1)C2=CC(Br)=C(F)C(F)=C2NC3=CC=C(I)C=C3Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |