anti-NCAM1 immunotoxin N901 (IgG)-RTA
This immunotoxin was achieved by conjugating/fusing the Anti-NCAM1 monoclonal antibody to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to small-cell lung cancer (SCLC) cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of small-cell lung cancer (SCLC).
| Supplier | Creative Biolabs |
|---|---|
| Product # | AGTO-L037R |
| Pricing | Inquiry |
| Applications | This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy. |
| Host | Mouse |
| Target | NCAM1 |
| Species Reactivity | Human |