CP-316311
CP-316311 is a potent and selective CRF 1 receptor antagonist with an IC50 value of 6.8 nM in receptor binding and demonstrates oral efficacy in central nervous system (CNS) in vivo models. CP-316311 was advanced to phase II depression trials to test the hypothesis that CRF 1 antagonists could be used clinically as antidepressant drugs.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD743 |
| CAS # | 175139-41-0 |
| Pricing | Customizable size, Inquiry |
| Synonym | CP-316311; CP 316311; CP316311; CP-316,311; CP 316,311; CP316,311. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C21H29NO2 |
| Exact Mass | 327.2198 |
| Molecular Weight | 327.468 |
| Elemental Analysis | C, 77.02; H, 8.93; N, 4.28; O, 9.77 |
| IUPAC/Chemical Name | 3,6-dimethyl-4-pentan-3-yloxy-2-(2,4,6-trimethylphenoxy)pyridine |
| InChi Key | ZSEJGVQTBLJRCQ-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C21H29NO2/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5/h10-12,18H,8-9H2,1-7H3 |
| SMILES Code | CC1=C(OC2=NC(C)=CC(OC(CC)CC)=C2C)C(C)=CC(C)=C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |