nAChR agonist 1

Supplier MedChemExpress
Product # HY-133011-25 mg
CAS # 1394371-75-5
Pricing 25 mg, USD $1650.0
Biological Activity nAChR agonist 1 is a potent, brain-permeable, and orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR). nAChR agonist 1 has the EC50 of 0.32 µM in a Ca2+ mobilization assay (PNU-282987-induced, FLIPR based) in human IMR-32 neuroblastoma cells that endogenously express α7 nAChR. nAChR agonist 1 can be develpoped for the treatment of Alzheimer’s disease[1].
Purity 98.02%
MWt 419.94
Formula C₂₀H₁₈ClNO₃S₂
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