Amylin (rat)
Amylin (rat), islet Amyloid Polypeptide (IAPP), is a glucoregulatory peptide from rat pancreatic cells. It inhibits glucagon secretion, delays gastric emptying and acts as a satiety agent. It is used to study the regulation of satiety and obesity. It binds to heteromeric complexes of human calcitonin receptor 2 (CTR2) with receptor activity-modifying protein (RAMP) 1 or 3. It also binds to mouse α-thyroid-stimulating hormone thyrotroph (α-TSH) cells and rat nucleus accumbens membrane preparations. It inhibits insulin-induced, but not basal, glycogen synthesis in hepatocytes isolated from fasted rats in vitro. It does not form fibrils and is not cytotoxic unlike human amylin. It is active in vivo.
Supplier | BOC Sciences |
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Product # | BAT-010438 |
Pricing | Inquire |
Cas | 124447-81-0 |
Molecular Weight | 3920.43 |
Molecular Formula | C167H272N52O53S2 |
Canonical SMILES | CC1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N1)C(C)O)CC(=O)N)NC(=O)C(CCCCN)N)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CC(=O)N)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(CC(=O)N)C(=O)NC(CC(C)C)C(=O)NCC(=O)N3CCCC3C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC6=CC=C(C=C6)O)C(=O)N)C(C)O |