Ansofaxine HCl
Ansofaxine, also known as toludesvenlafaxine, is a triple reuptake inhibitor, targeting serotonin, dopamine and norepinephrine. Toludesvenlafaxine had high binding affinity on SERT, NET and DAT, and significantly inhibited the reuptake of serotonin (IC50 = 31.4 ± 0.4 nM), norepinephrine (IC50 = 586.7 ± 83.6 nM) and dopamine (IC50 = 733.2 ± 10.3 nM) in vitro. Toludesvenlafaxine demonstrated significant antidepressant-like effects in rat models at 8-16 mg/kg. In addition, toludesvenlafaxine significantly reduced serum corticosterone and significantly increased testosterone levels in rats.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD684 |
| CAS # | 916918-84-8 (HCl) |
| Pricing | Customizable size, Inquiry |
| Synonym | Ansofaxine HCl; Ansofaxine hydrochloride; Toludesvenlafaxine; LPM570065; LPM 570065; LPM-570065; LY03005; LY-03005; LY 03005; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C24H32ClNO3 |
| Molecular Weight | 417.974 |
| Elemental Analysis | C, 68.97; H, 7.72; Cl, 8.48; N, 3.35; O, 11.48 |
| IUPAC/Chemical Name | 4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenyl 4-methylbenzoate hydrochloride |
| InChi Key | BVWFJKQJRNSYCR-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C24H31NO3.ClH/c1-18-7-9-20(10-8-18)23(26)28-21-13-11-19(12-14-21)22(17-25(2)3)24(27)15-5-4-6-16-24;/h7-14,22,27H,4-6,15-17H2,1-3H3;1H |
| SMILES Code | O=C(OC1=CC=C(C(C2(O)CCCCC2)CN(C)C)C=C1)C3=CC=C(C)C=C3.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |