Lumateperone tosylate
Lumateperone toluenesulfonic acid or Lumateperone PTSA salt, also known as ITI-722 or ITI-007, is a highly potent 5HT2A antagonist for the treatment of sleep maintenance insomnia. Preclinical data has shown that ITI-722 is not sedating and should not exhibit next day hangover effects that are commonly associated with other sleep medications. ITI-722 is expected to have a strong safety profile with no addiction liability.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1290 |
| CAS # | 1187020-80-9 (tosylate) |
| Pricing | Customizable size, Inquiry |
| Synonym | ITI-722; ITI722; ITI 722; ITI-007; ITI007; ITI 007; Lumateperone, Caplyta, |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C31H36FN3O4S |
| Exact Mass | 393.2216 |
| Molecular Weight | 565.7044 |
| Elemental Analysis | C, 65.82; H, 6.41; F, 3.36; N, 7.43; O, 11.31; S, 5.67 |
| IUPAC/Chemical Name | 1-(4-fluorophenyl)-4-[(6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]butan-1-one toluenesulfonic acid |
| InChi Key | LHAPOGAFBLSJJQ-GUTACTQSSA-N |
| InChi Code | InChI=1S/C24H28FN3O.C7H8O3S/c1-26-14-15-28-21-11-13-27(16-20(21)19-4-2-5-22(26)24(19)28)12-3-6-23(29)17-7-9-18(25)10-8-17;1-6-2-4-7(5-3-6)11(8,9)10/h2,4-5,7-10,20-21H,3,6,11-16H2,1H3;2-5H,1H3,(H,8,9,10)/t20-,21-;/m0./s1 |
| SMILES Code | O=C(C1=CC=C(F)C=C1)CCCN2CC[C@@](N3CCN(C)C4=C3C5=CC=C4)([H])[C@@]5([H])C2.CC6=CC=C(S(=O)(O)=O)C=C6 |
| Appearance | Solid powder |
| Purity | >98% (chemical purity); > 98%(optical purity). |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Schizophrenia |
| Availability | 2 Weeks |