Harmalol HCl hydrate
Harmalol HCl hydrate is a β-carboline alkaloid and an active metabolite of harmaline that has been found in P. harmala and has diverse biological activities. It is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A; IC50 = 0.63 µM) and monoamine oxidase A (MAO-A; IC50 = 0.66 µM). It is selective for DYRK1A over Cdk1, Cdk5, CK1α1, Clk4, DYRK2, Pim-1, and GSK3β but also inhibits DYRK1B and Clk1 at 10 µM. It inhibits proliferation of H4 human glioblastoma cells (IC50s = 23.7 µM). Harmalol (0.5-12.5 µM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts. It reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells when used at a concentration of 25 µM. This product is also available as an analytical reference standard.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD852 |
| CAS # | 6028-00-8 |
| Pricing | Customizable size, Inquiry |
| Synonym | 11-hydroxy Harmalan; Harmidol; Harmalol; Harmalol hydrochloride hydrate; 11hydroxy Harmalan; 11 hydroxy Harmalan |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C12H17ClN2O3 |
| Molecular Weight | 272.73 |
| Elemental Analysis | C, 52.85; H, 6.28; Cl, 13.00; N, 10.27; O, 17.60 |
| IUPAC/Chemical Name | 1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol hydrochloride dihydrate |
| InChi Key | OYKGNQNESCZSHQ-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C12H12N2O.ClH.2H2O/c1-7-12-10(4-5-13-7)9-3-2-8(15)6-11(9)14-12;;;/h2-3,6,14-15H,4-5H2,1H3;1H;2*1H2 |
| SMILES Code | OC1=CC=C2C(NC3=C2CCN=C3C)=C1.Cl.O.O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |