A-9758
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-126252 |
| CAS # | 2055271-22-0 |
| Pricing | inquire |
| Biological Activity | A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation[1]. |
| MWt | 527.36 |
| Formula | C₂₅H₂₃Cl₂F₃N₂O₃ |