Nonactin
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-N6790-10 mM * 1 mL |
| CAS # | 6833-84-7 |
| Pricing | 10 mM * 1 mL, USD $730.0 |
| Synonyms | Ammonium ionophore I |
| MWt | 736.93 |
| Formula | C₄₀H₆₄O₁₂ |
| Biological Activity | Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+[1]. Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin[2]. Nonactin inhibits the surface expression of endogenous HSP60[3]. |
| Purity | ≥99.0% |