Adavosertib (MK-1775)

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Adavosertib (MK-1775, AZD1775) is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM in a cell-free assay; hinders G2 DNA damage checkpoint. Phase 2.

Supplier	Selleck Chemicals
Product #	S1525
Sku #	S1525-100mg
Pricing	100mg, $589.00

Citations for this product:

Exploiting collateral sensitivity controls growth of mixed culture of sensitive and resistant cells and decreases selection for resistant cells

Vince Kornél Grolmusz, et al., bioRxiv - Systems Biology 2020

Quote: ... Resistance and collateral sensitivity against adavosertib (Selleck Chemicals, Cat. No.: S1525) were detected by the alteration of the dose-response curve measured using CellTiterGlo Chemoluminescent Kit (Promega Corporation ...
Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1

Devashish Dwivedi, Daniela Harry, Patrick Meraldi, bioRxiv - Cell Biology 2022

Quote: ... and Wee1: 0.5 µM MK-1775 (Selleck Chemicals: S1525).

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