PF-06256142
PF-06256142 is a potent and selective orthosteric agonist of the D1 receptor with D1 EC50=30 nM and D1 binding Ki = 12 nM. PF-06256142 may be useful for treatment of Parkinson’s disease (PD) and schizophrenia. PF-06256142 has reduced receptor desensitization relative to dopamine and other catechol-containing agonists. PF-06256142 has the (+)-Enantiomer with [α]20/D = +35.2 (c 0.32, CH2Cl2). The pharmacokinetic properties of PF-06256142 such as metabolic stability, high passive permeability, and low MDR and BCRP efflux ratios make this compound suitable for oral dosing and in vivo study.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1656 |
| CAS # | 1609583-14-3 (rotation +) |
| Pricing | Customizable size, Inquiry |
| Synonym | PF-06256142; PF 06256142; PF06256142; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C21H16N4O2 |
| Exact Mass | 356.1273 |
| Molecular Weight | 356.385 |
| Elemental Analysis | C, 70.77; H, 4.53; N, 15.72; O, 8.98 |
| IUPAC/Chemical Name | (+)-4-(3-Methyl-4-(6-methylimidazo[1,2-a]pyrazin-5-yl)phenoxy)furo[3,2-c]-pyridine |
| InChi Key | HWAIAGZSWHOLLK-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C21H16N4O2/c1-13-11-15(27-21-17-6-10-26-18(17)5-7-23-21)3-4-16(13)20-14(2)24-12-19-22-8-9-25(19)20/h3-12H,1-2H3 |
| SMILES Code | CC1=CC(OC2=NC=CC3=C2C=CO3)=CC=C1C4=C(N=CC5=NC=CN45)C |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.03.00 |