NKH477
NKH477 is a potent activator of adenylyl cyclase. NKH477 shows some selectivity for cardiac (type V) adenylyl cyclase. NKH477 stimulates bronchodilation (EC50 = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive agent in vivo.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1016 |
| CAS # | 138605-00-2 |
| Pricing | Customizable size, Inquiry |
| Synonym | NKH477; NKH 477; NKH-477. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C28H45ClO8 |
| Exact Mass | 544.2803 |
| Molecular Weight | 545.11 |
| Elemental Analysis | C, 61.70; H, 8.32; Cl, 6.50; O, 23.48 |
| IUPAC/Chemical Name | (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2,1-b]pyran-6-yl 4-methylpentanoate hydrochloride |
| InChi Key | LNEICJSEZPSKSJ-RPBMHHKSSA-N |
| InChi Code | InChI=1S/C28H44O8.ClH/c1-10-25(7)15-19(31)28(33)26(8)18(30)13-14-24(5,6)22(26)21(35-20(32)12-11-16(2)3)23(34-17(4)29)27(28,9)36-25;/h10,16,18,21-23,30,33H,1,11-15H2,2-9H3;1H/t18-,21-,22-,23-,25-,26-,27+,28-;/m0./s1 |
| SMILES Code | CC(C)CCC(O[C@@H]([C@@]1([H])C(C)(C)CC[C@H](O)[C@@]12C)[C@H](OC(C)=O)[C@]3(C)[C@]2(O)C(C[C@](C)(C=C)O3)=O)=O.[H]Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |