ND-7001
ND-7001is a PDE2 (phosphodiesterase-2) inhibitor in development by Neuro3d for treatment of Alzheimer's disease, as well as depression and anxiety (by targeting the nitric-oxide synthase pathway). It shows an IC50 of 50 nM against PDE2 and good selectivity over PDE3 and PDE4. General safety, tolerability, and pharmacokinetics characteristics were determined to be good in high doses without adverse side effects.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD305 |
| CAS # | N/A |
| Pricing | Customizable size, Inquiry |
| Synonym | ND-7001; ND7001; ND 7001 |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C24H21N3O3 |
| Exact Mass | 399.1583 |
| Molecular Weight | 399.45 |
| Elemental Analysis | C, 72.17; H, 5.30; N, 10.52; O, 12.02 |
| IUPAC/Chemical Name | 3-(8-methoxy-1-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)benzamide |
| InChi Key | WYTGWTBNDXWMMB-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C24H21N3O3/c1-27-20-13-21(30-2)18(15-7-4-3-5-8-15)12-19(20)23(26-14-22(27)28)16-9-6-10-17(11-16)24(25)29/h3-13H,14H2,1-2H3,(H2,25,29) |
| SMILES Code | O=C(N)C1=CC=CC(C2=NCC(N(C)C3=CC(OC)=C(C4=CC=CC=C4)C=C32)=O)=C1 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |